Mouse Anti-DOG-1 / TMEM16A Antibody MBS4380014 from MyBioSource.com

Product Specs
ItemMouse Anti-DOG-1 / TMEM16A Antibody
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS4380014
Quantity0.02 mg (With BSA & Azide at 0.2mg/ml)
ApplicationsFlow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
Conjugate/TagUnconjugated
FormatBioreactor Concentrate with 0.05% Azide
ReactivityHuman
TargetDOG-1 / TMEM16A
IsotypeIgG1 kappa
Molecular Weight~114 kDa
CloneDG1/447
HostMouse
ImmunogenExpression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha (PDGFR alpha) mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%
NCBI Full Gene Nameanoctamin 1
NCBI Gene AliasesORAOV2, TMEM16A, TAOS2, DOG1
ClonalityMonoclonal